Having heard of attempts around the world to buy most or all of the ticket combinations for a draw in an attempt to win enough prizes to make a handsome profit (this happened once in the Irish lottery for instance), it seemed an obvious first What If...? question. Besides, I've been e-mailed on several occasions with this very question and haven't been able to provide a definitive answer to the question of someone buying up all 13,983,816 ticket combinations and how this would impact the UK lottery.
Of course, you'd need 2 million playslips and some computer software to print out all the combinations in a sort of "human way" (i.e. with a random pen mark so it doesn't look like it's done by software). Retailers probably won't accept playslips that are entirely printed by third party computer, but that could be an avenue worth trying - a good quality double-sided colour printer would be needed, although you'd no doubt be breaking copyright by reproducing playslips in this manner (and risk having entries voided by Camelot).
It's also hard to see how the Press (and Camelot themselves) wouldn't catch wind of all this - all the retailers and playslip feeders would have to be paid handsomely for their work and to keep quiet about it. If the story did break, then ticket sales would be further boosted by people thinking that it's a bigger draw (though in reality, the majority of extra prizes would go to the additional 14 million tickets).
By now, you'll have realised that to make a profit when buying all the ticket combinations, you have to rely on not sharing the higher tier prizes (particularly the jackpot and 5+bonus prizes) with too many other tickets. This is such a risk that it effectively rules out it ever being tried in real life.
There is one circumstance, of course, where there's maximum profit to be made - where the jackpot wasn't won in the original draw. Unfortunately, in real life this would cancel the next draw's rollover and this fact has had to be ignored when calculating the change for each draw (there's no easy way to compensate for a theoretical lack of a rollover).
One other factor could affect profit and that's rollovers (or Super Draws). However, this is even riskier than usual because the jackpot gets all the rollover/Super Draw additional funds, so to make a profit, the jackpot has to be won outright by one of the additional ticket combinations. However, real life attempts might concentrate on these types of draws, so I've provided additional pages which just list the changes to those draws.